Scientists Have Created a Method To Prevent Deadly Infections Without Antibiotics

Scientists Have Created a Method To Prevent Deadly Infections Without Antibiotics

UCLA researchers have developed a new level of treatment that prevents bacteria from adhering to medical devices like catheters and stents. A hospital or medical clinic seems like the last place you would expect an infection badly, yet almost 1 every year. 1.7 million Americans suffer, nearly 100,000 deaths from infection – related complications and $30 billion in direct medical expenses.

According to experts, medical supplies such as catheters, stents, heart valves, and pacemakers are the primary culprits, which account for two-thirds of all infections. Their surfaces are often coated with dangerous bacterial films. However, a unique level treatment developed by a team led by the University of California, Los Angeles (UCLA) scientists can help improve the security of these devices while also reducing the financial stress on the health care system.

The new technique, which has been experimented in both laboratory and clinical settings, involves assembling a thin coating of zitronic content on a device’s surface and permanently binding that layer to the core using ultraviolet light radiation. The resultant barrier prevents germs and other potentially dangerous organic materials from penetrating the surface and infecting people. The team results were published in the journal Advanced Materials on 19th May 2022.

Harmful bacteria medical devices.

Harmful germs grow freely on applied medical devices. A new way of applying surface-coating treatments to medical devices is likely to improve their safety, reduce patient complications and deaths. Credit : Amir Sheikhhi / Penn State In the laboratory, researchers applied surface treatment to several commonly used medical device materials, then tested resistance of the modified materials against a variety of bacteria, cookies and proteins. They found that, depending on microbial stress from treatment, decreased biofilm growth by more than 80%—and increased by 93% in some cases.

“Modified levels demonstrated strong resistance against microgenisms and proteins, which is exactly what we sought to achieve,” UCLA’s Dr. Richard Conner said. Myung Ki Hong Professor of Minerals Senior Author of Innovation and Research. “The levels have very little or even prevented the formation of the biofilm.”

Richard Conner

Senior author of research, Richard Conner. Credit: Red Hutchinson / UCLA
“And our preliminary medical results are remarkable,” Connor added.
Clinical research included 16 long-term urine catheter users who turned to silicone catheters with new zotronic level treatments. This modified catheter is the first company Connor founded from his own lab, called SILQ Technologies Corporation. , and has been cleared by the Food and Drug Administration for use in patients.
Ten patients described their urinary tract condition using level-treated catheters “far better” or “very better,” and 13 opted to continue using new catheters over traditional latex and silicone options after the study ended.
“A few weeks ago a patient came to UCLA to thank us for changing his life — something that as a content scientist, I never thought was possible.” Connor said.

“His previous catheters will be blocked in four days or so.” She was in pain and needed repeated medical procedures to replace them. With our level of treatment, she comes every three weeks now, and her catheters work perfectly like a normal occurrence with her previous incidences—without any pressure or magic—
Such catheter-related urinary tract problems are examples of issues affecting other medical devices, which, once inserted or installed, increased for the growth of bacteria and harmful biofilm, Kuner said. Can Foundation, a member of the California Nano System Institute at UCLA who is a distinguished professor of chemistry and biochemistry, and also of materials science and engineering. Robotic cells are pumped by these highly elastic biofilms then cause repeated infections in the body.

In response, medical staff routinely administer strong antibiotics to patients using these devices, a short – term correct that poses a long – life-threatening “superbug” infection. Connor said the more widely and frequently antibiotics are prescribed, the more likely bacteria will create resistance to them. A key 2014 World Health Organization report recognized antibiotic abuse as a public health risk, with officials calling for an aggressive response to prevent a post-antibiotic era in which common Infections and minor injuries that have been treatable for decades can kill again

“The beauty of this technology,” Conner said, “is that it can prevent or reduce the development of biofilm without the use of antibiotics.” It protects the patients who use medical devices—and therefore protects all of us from microbial resistance and the spread of wonderful people

Surface treatment zeterine polymers are known to be highly biocompatible, and they absorb water very strongly, creating a thin barrier of hydration that blocks bacteria, cookies, Connor said, and other organic materials From practicing on the levels. And, he noted, this technology is highly effective, non-toxic, and relatively low in current levels of treatments for medical devices, such as antibiotic—or silver—infused refinement.

Kenner said that aside from its use in medical devices, the surface-themedical technique could have non-medical applications, potentially extending water life-long treatment and improving lithium-ion battery performance Yes.
Funding sources for the study included the National Health Organization, National Science Foundation, the Canadian Institute of Health Research, SILQ Technologies Corporation, and the UCLA Sustainability Grand Challenge.

Reference: “A readable, medically demonstrated, anti-biofouling zotronic level treatment for ineffective medical devices” Brian McCurry, Alexandra Polasco, Ethan Rao, Rihanna Hagniaz, Deong-chan, Nahe, Pia Ramos, Joel Hayashi, Paige Krison, Chea-Yu Wo, Parvin Bendaro, Mackenzie Anderson, Brandon Boye, Arif Seig, Shelly Mahendra, Dono Di Carlo, Eugene Curdien, Ali Khadimousini, Amir Sheikhi and Richard B. Connor, March 22, 2022, premium content.

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